Assay Detail
Binding
CHEMBL715385
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Inhibitory activity against human matrix metalloprotease-1 in quenched fluorescence assay at pH 7.4
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.30 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10671 | — | — | 1 | 6.20 |
| CHEMBL10454 | — | — | 1 | 5.70 |
| CHEMBL10672 | — | — | 1 | 5.49 |
| CHEMBL10953 | — | — | 1 | 5.48 |
| CHEMBL10674 | — | — | 1 | 5.47 |
| CHEMBL10655 | — | — | 1 | 5.44 |
| CHEMBL10935 | — | — | 1 | 5.38 |
| CHEMBL10469 | — | — | 1 | 5.25 |
| CHEMBL274881 | — | — | 1 | 5.21 |
| CHEMBL10266 | — | — | 1 | 5.19 |
| CHEMBL10881 | — | — | 1 | 4.99 |
| CHEMBL10335 | — | — | 1 | 4.94 |
| CHEMBL10806 | — | — | 1 | 4.86 |
| CHEMBL10809 | — | — | 1 | 4.61 |
| CHEMBL10673 | — | — | 1 | - |
| CHEMBL275754 | — | — | 1 | - |
| CHEMBL417977 | — | — | 1 | - |
| CHEMBL10193 | — | — | 1 | - |
| CHEMBL10646 | — | — | 1 | - |
| CHEMBL10822 | — | — | 1 | - |
| CHEMBL10760 | — | — | 1 | - |
| CHEMBL276016 | — | — | 1 | - |
| CHEMBL10257 | — | — | 1 | - |
| CHEMBL274997 | — | — | 1 | - |
| CHEMBL10492 | — | — | 1 | - |
| CHEMBL10761 | — | — | 1 | - |
| CHEMBL10296 | — | — | 1 | - |
| CHEMBL275345 | — | — | 1 | - |
| CHEMBL10908 | — | — | 1 | - |
| CHEMBL10848 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10671 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL10454 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL10672 | — | IC50 | = | 3250.0 | nM | 5.49 |
| CHEMBL10953 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL10674 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL10655 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL10935 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL10469 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL274881 | — | IC50 | = | 6150.0 | nM | 5.21 |
| CHEMBL10266 | — | IC50 | = | 6510.0 | nM | 5.19 |
| CHEMBL10881 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL10335 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL10806 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL10809 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL10952 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10851 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL268050 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10180 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10792 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL275700 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL11005 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10885 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL11188 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL275130 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10673 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL275754 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL417977 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10193 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10646 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10822 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10760 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL276016 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10257 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL274997 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10492 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10761 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10296 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL275345 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10908 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10848 | — | IC50 | > | 10000.0 | nM | - |