Assay Detail
Binding
CHEMBL715559
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Inhibitory activity against Matrix metalloprotease-9
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Komagataella pastoris |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Identification of highly selective inhibitors of collagenase-1 from combinatorial libraries of diketopiperazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.97 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424407 | — | — | 1 | 7.28 |
| CHEMBL29897 | — | — | 1 | 7.10 |
| CHEMBL30034 | — | — | 1 | 6.40 |
| CHEMBL287632 | — | — | 1 | 6.24 |
| CHEMBL25788 | — | — | 1 | 5.93 |
| CHEMBL30134 | — | — | 1 | 5.92 |
| CHEMBL251687 | — | — | 1 | 5.92 |
| CHEMBL27408 | — | — | 1 | 5.89 |
| CHEMBL282581 | — | — | 1 | 5.89 |
| CHEMBL284422 | — | — | 1 | 5.82 |
| CHEMBL286254 | — | — | 1 | 5.77 |
| CHEMBL29801 | — | — | 1 | 5.58 |
| CHEMBL26913 | — | — | 1 | 5.54 |
| CHEMBL30055 | — | — | 1 | 5.50 |
| CHEMBL280824 | — | — | 1 | 5.37 |
| CHEMBL29505 | — | — | 1 | 5.36 |
| CHEMBL29986 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424407 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL29897 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL30034 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL287632 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL25788 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL30134 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL251687 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL27408 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL282581 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL284422 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL286254 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL29801 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL26913 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL30055 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL280824 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL29505 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL29986 | — | IC50 | > | 40000.0 | nM | - |