Assay Detail
Binding
CHEMBL715569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration for half maximal activation of metabotropic glutamate mGluR8 in mouse
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Metabotropic glutamate receptors: novel targets for drug development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.03 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 7.66 |
| CHEMBL33567 | — | — | 1 | 6.40 |
| CHEMBL34453 | — | — | 1 | - |
| CHEMBL279956 | QUISQUALATE | — | 1 | - |
| CHEMBL30285 | IBOTENIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL33567 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL34453 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL279956 | QUISQUALATE | EC50 | > | 100000.0 | nM | - |
| CHEMBL30285 | IBOTENIC ACID | EC50 | > | 100000.0 | nM | - |