Assay Detail
Functional
CHEMBL715576
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Antagonistic activity against metabotropic glutamate receptor 2 (mGluR2) was evaluated
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 2 (CHEMBL2851) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.88 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432038 | — | — | 1 | 6.70 |
| CHEMBL95868 | — | — | 1 | 5.88 |
| CHEMBL97200 | — | — | 1 | 5.86 |
| CHEMBL319279 | — | — | 1 | 5.78 |
| CHEMBL319732 | — | — | 1 | 5.73 |
| CHEMBL420262 | — | — | 1 | 5.67 |
| CHEMBL439775 | — | — | 1 | 5.54 |
| CHEMBL99462 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432038 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL95868 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL97200 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL319279 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL319732 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL420262 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL439775 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL99462 | — | IC50 | > | 10000.0 | nM | - |