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Assay Detail

CHEMBL715738

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Functional
Anti-HIV activity protecting MT-4 cells from HIV-1 induced cytopathogenicity
ChEMBL ↗
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.
Silvestri R, De Martino G, La Regina G, Artico M, Massa S, Vargiu L, Mura M, Loi AG, Marceddu T, La Colla P.
J Med Chem (2003) 46 : 2482 -2493
PubMed 12773052 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 70 6.64 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL283950 L-737126 — 1 9.00
CHEMBL83800 — — 1 9.00
CHEMBL82106 — — 1 9.00
CHEMBL82533 — — 1 8.70
CHEMBL84217 — — 1 8.52
CHEMBL85059 — — 1 8.40
CHEMBL315349 — — 1 8.40
CHEMBL312702 — — 1 8.22
CHEMBL81097 — — 1 8.00
CHEMBL263503 — — 1 7.96
CHEMBL80045 — — 1 7.85
CHEMBL84002 — — 1 7.82
CHEMBL286759 — — 1 7.70
CHEMBL310319 — — 1 7.60
CHEMBL312251 — — 1 7.40
CHEMBL419108 — — 1 7.30
CHEMBL314697 — — 1 7.10
CHEMBL79797 — — 1 7.00
CHEMBL80022 — — 1 7.00
CHEMBL84522 — — 1 6.89
CHEMBL431798 — — 1 6.75
CHEMBL79337 — — 1 6.70
CHEMBL310464 — — 1 6.52
CHEMBL311605 — — 1 6.52
CHEMBL84101 — — 1 6.52
CHEMBL83495 — — 1 6.52
CHEMBL82471 — — 1 6.30
CHEMBL79398 — — 1 6.30
CHEMBL84534 — — 1 5.92
CHEMBL313624 — — 1 5.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL283950 L-737126 EC50 = 1.0 nM 9.00
CHEMBL83800 — EC50 = 1.0 nM 9.00
CHEMBL82106 — EC50 = 1.0 nM 9.00
CHEMBL82533 — EC50 = 2.0 nM 8.70
CHEMBL84217 — EC50 = 3.0 nM 8.52
CHEMBL85059 — EC50 = 4.0 nM 8.40
CHEMBL315349 — EC50 = 4.0 nM 8.40
CHEMBL312702 — EC50 = 6.0 nM 8.22
CHEMBL81097 — EC50 = 10.0 nM 8.00
CHEMBL263503 — EC50 = 11.0 nM 7.96
CHEMBL80045 — EC50 = 14.0 nM 7.85
CHEMBL84002 — EC50 = 15.0 nM 7.82
CHEMBL286759 — EC50 = 20.0 nM 7.70
CHEMBL310319 — EC50 = 25.0 nM 7.60
CHEMBL312251 — EC50 = 40.0 nM 7.40
CHEMBL419108 — EC50 = 50.0 nM 7.30
CHEMBL314697 — EC50 = 80.0 nM 7.10
CHEMBL79797 — EC50 = 100.0 nM 7.00
CHEMBL80022 — EC50 = 100.0 nM 7.00
CHEMBL84522 — EC50 = 130.0 nM 6.89
CHEMBL431798 — EC50 = 180.0 nM 6.75
CHEMBL79337 — EC50 = 200.0 nM 6.70
CHEMBL83495 — EC50 = 300.0 nM 6.52
CHEMBL84101 — EC50 = 300.0 nM 6.52
CHEMBL310464 — EC50 = 300.0 nM 6.52
CHEMBL311605 — EC50 = 300.0 nM 6.52
CHEMBL82471 — EC50 = 500.0 nM 6.30
CHEMBL79398 — EC50 = 500.0 nM 6.30
CHEMBL84534 — EC50 = 1200.0 nM 5.92
CHEMBL313624 — EC50 = 1400.0 nM 5.85
CHEMBL83783 — EC50 = 1400.0 nM 5.85
CHEMBL84245 — EC50 = 1400.0 nM 5.85
CHEMBL82052 — EC50 = 1500.0 nM 5.82
CHEMBL312102 — EC50 = 1600.0 nM 5.80
CHEMBL82415 — EC50 = 1800.0 nM 5.75
CHEMBL83833 — EC50 = 1900.0 nM 5.72
CHEMBL83793 — EC50 = 1900.0 nM 5.72
CHEMBL84208 — EC50 = 2300.0 nM 5.64
CHEMBL311895 — EC50 = 2500.0 nM 5.60
CHEMBL84510 — EC50 = 2500.0 nM 5.60
CHEMBL314618 — EC50 = 3100.0 nM 5.51
CHEMBL313011 — EC50 = 3700.0 nM 5.43
CHEMBL445364 — EC50 = 5000.0 nM 5.30
CHEMBL82094 — EC50 = 8000.0 nM 5.10
CHEMBL84372 — EC50 = 8300.0 nM 5.08
CHEMBL79826 — EC50 = 9000.0 nM 5.05
CHEMBL79468 — EC50 = 10000.0 nM 5.00
CHEMBL84300 — EC50 = 15000.0 nM 4.82
CHEMBL311883 — EC50 = 66000.0 nM 4.18
CHEMBL313989 — EC50 > 200000.0 nM -