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Assay Detail

CHEMBL715739

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anti-HIV activity to reduce HIV-1-induced cytopathic effect by 50% in MT-4 cells against HIV-1 IIIB
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MT4
Confidence 1 — Organism
Curated By Intermediate

Target

MT4 (CHEMBL388)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.
Barreca ML, Chimirri A, De Luca L, Monforte AM, Monforte P, Rao A, Zappalà M, Balzarini J, De Clercq E, Pannecouque C, Witvrouw M.
Bioorg Med Chem Lett (2001) 11 : 1793 -1796
PubMed 11425562 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 13 6.11 7.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL48427 1 7.36
CHEMBL296589 1 7.09
CHEMBL300179 1 6.83
CHEMBL50805 1 6.75
CHEMBL50019 1 6.61
CHEMBL53554 THIAZOLOBENZIMIDAZOLE 1 6.45
CHEMBL299364 1 6.40
CHEMBL296175 1 6.23
CHEMBL50948 1 6.07
CHEMBL53540 1 5.29
CHEMBL50428 1 4.27
CHEMBL300859 1 4.02
CHEMBL51254 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL48427 EC50 = 44.0 nM 7.36
CHEMBL296589 EC50 = 82.0 nM 7.09
CHEMBL300179 EC50 = 147.0 nM 6.83
CHEMBL50805 EC50 = 178.0 nM 6.75
CHEMBL50019 EC50 = 248.0 nM 6.61
CHEMBL53554 THIAZOLOBENZIMIDAZOLE EC50 = 352.0 nM 6.45
CHEMBL299364 EC50 = 401.0 nM 6.40
CHEMBL296175 EC50 = 589.0 nM 6.23
CHEMBL50948 EC50 = 855.0 nM 6.07
CHEMBL53540 EC50 = 5130.0 nM 5.29
CHEMBL50428 EC50 = 53500.0 nM 4.27
CHEMBL300859 EC50 = 95100.0 nM 4.02
CHEMBL51254 EC50 > 23000.0 nM -