Assay Detail
Functional
CHEMBL715744
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV-1 activity against Y181C HIV-1 strain in MT-4 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.68 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.60 |
| CHEMBL85946 | — | — | 1 | 6.52 |
| CHEMBL309899 | — | — | 1 | 5.92 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
| CHEMBL310803 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL85946 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL309899 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 30000.0 | nM | - |
| CHEMBL310803 | — | EC50 | > | 10000.0 | nM | - |