Assay Detail
Functional
CHEMBL715745
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Antiviral activity against HIV-1 in MT-4 cells was evaluated by using a clinical strain (HE)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationship studies with symmetric naphthalenesulfonic acid derivatives. Synthesis and influence of spacer and naphthalenesulfonic acid moiety on anti-HIV-1 activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.21 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2092850 | — | — | 1 | 5.66 |
| CHEMBL2092851 | — | — | 1 | 5.41 |
| CHEMBL1744433 | — | — | 1 | 5.12 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 5.10 |
| CHEMBL1788183 | — | — | 1 | 5.09 |
| CHEMBL1788172 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2092850 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2092851 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1744433 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL265502 | SURAMIN | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1788183 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL1788172 | — | EC50 | = | 12500.0 | nM | 4.90 |