Assay Detail
Functional
CHEMBL715971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against human breast adenocarcinoma MCF-7 cells.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antitumor agents. 2. Synthesis, structure-activity relationships, and biological evaluation of substituted 5H-pyridophenoxazin-5-ones with potent antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.51 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 8.22 |
| CHEMBL148576 | — | — | 1 | 8.00 |
| CHEMBL147140 | — | — | 1 | 8.00 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.30 |
| CHEMBL346174 | — | — | 1 | 7.19 |
| CHEMBL151423 | — | — | 1 | 6.64 |
| CHEMBL147017 | — | — | 1 | 6.52 |
| CHEMBL347271 | — | — | 1 | 6.52 |
| CHEMBL151875 | — | — | 1 | 6.30 |
| CHEMBL149774 | — | — | 1 | 6.30 |
| CHEMBL348701 | — | — | 1 | 6.22 |
| CHEMBL148592 | — | — | 1 | 6.22 |
| CHEMBL357353 | — | — | 1 | 6.16 |
| CHEMBL147392 | — | — | 1 | 5.92 |
| CHEMBL149317 | — | — | 1 | 5.50 |
| CHEMBL148722 | — | — | 1 | 4.86 |
| CHEMBL422497 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL148576 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL147140 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL346174 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL151423 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL147017 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL347271 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL151875 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL149774 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL348701 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL148592 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL357353 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL147392 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL149317 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL148722 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL422497 | — | IC50 | = | 15200.0 | nM | 4.82 |