Assay Detail
Functional
CHEMBL716352
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Agonistic potency towards human Melanocortin 3 receptor (MC3R) was determined by 50% maximum cAMP release
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.75 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423101 | — | — | 1 | 5.80 |
| CHEMBL349850 | — | — | 1 | 5.75 |
| CHEMBL338594 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423101 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL349850 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL338594 | — | EC50 | = | 2000.0 | nM | 5.70 |