Assay Detail
Binding
CHEMBL716368
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Inhibitory activity against human melanocortin 3 receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of novel melanocortin 4 receptor agonists and antagonists containing a succinamide core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.45 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3348530 | — | — | 1 | 7.36 |
| CHEMBL338768 | — | — | 1 | 5.54 |
| CHEMBL337940 | — | — | 1 | - |
| CHEMBL125492 | — | — | 1 | - |
| CHEMBL338766 | — | — | 1 | - |
| CHEMBL123744 | — | — | 1 | - |
| CHEMBL125819 | — | — | 1 | - |
| CHEMBL332442 | — | — | 1 | - |
| CHEMBL338747 | — | — | 1 | - |
| CHEMBL332443 | — | — | 1 | - |
| CHEMBL127861 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3348530 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL338768 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL337940 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL125492 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL338766 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL123744 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL125819 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL332442 | — | IC50 | > | 3500.0 | nM | - |
| CHEMBL338747 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL332443 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL127861 | — | IC50 | > | 10000.0 | nM | - |