Assay Detail
Binding
CHEMBL717003
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Inhibition of Matrix metalloprotease-13
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Heterocycle-based MMP inhibitors with P2' substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.73 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7108 | — | — | 1 | 9.47 |
| CHEMBL269019 | — | — | 1 | 9.12 |
| CHEMBL427616 | — | — | 1 | 9.08 |
| CHEMBL7756 | — | — | 1 | 8.72 |
| CHEMBL6572 | — | — | 1 | 8.70 |
| CHEMBL267939 | — | — | 1 | 8.68 |
| CHEMBL268114 | — | — | 1 | 8.62 |
| CHEMBL7390 | — | — | 1 | 8.59 |
| CHEMBL268377 | — | — | 1 | 8.54 |
| CHEMBL514138 | CGS-27023A | — | 1 | 8.37 |
| CHEMBL6973 | — | — | 1 | 8.10 |
| CHEMBL415482 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7108 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL269019 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL427616 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL7756 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL6572 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL267939 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL268114 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL7390 | — | IC50 | = | 2.56 | nM | 8.59 |
| CHEMBL268377 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL6973 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL415482 | — | IC50 | - | nM | - |