Assay Detail
Binding
CHEMBL717244
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Concentration for half maximal activation of metabotropic glutamate mGluR3 in rat
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 3 (CHEMBL3067) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Metabotropic glutamate receptors: novel targets for drug development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.31 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284193 | — | — | 1 | 6.52 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 5.52 |
| CHEMBL34453 | — | — | 1 | 5.10 |
| CHEMBL30285 | IBOTENIC ACID | — | 1 | 5.00 |
| CHEMBL279956 | QUISQUALATE | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284193 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL34453 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL30285 | IBOTENIC ACID | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL279956 | QUISQUALATE | EC50 | = | 40000.0 | nM | 4.40 |