Assay Detail
Binding
CHEMBL717318
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Inhibition of MMP-1 (Matrix metalloprotease-1)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.84 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417537 | — | — | 1 | 9.06 |
| CHEMBL45631 | — | — | 1 | 8.92 |
| CHEMBL48258 | — | — | 1 | 8.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417537 | — | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL45631 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL48258 | — | Ki | = | 2.8 | nM | 8.55 |