Assay Detail
Binding
CHEMBL717334
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Compound was tested for the inhibition of Metabotropic glutamate receptor 1
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.07 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 5.31 |
| CHEMBL34453 | — | — | 1 | 4.82 |
| CHEMBL29726 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL34453 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL29726 | — | EC50 | > | 300000.0 | nM | - |