Assay Detail
Functional
CHEMBL717396
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In vitro cytotoxicity evaluated in mouse heart endotheliaoma cell (MHEC5-T) after incubation of the cells for 1 hr
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.09 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289351 | FOSBRETABULIN DISODIUM | 2.0 | 1 | 6.10 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.98 |
| CHEMBL37688 | — | — | 1 | 5.10 |
| CHEMBL34720 | — | — | 1 | 5.00 |
| CHEMBL289910 | — | — | 1 | 4.60 |
| CHEMBL36775 | — | — | 1 | 4.46 |
| CHEMBL37961 | — | — | 1 | 4.42 |
| CHEMBL38061 | — | — | 1 | - |
| CHEMBL284289 | — | — | 1 | - |
| CHEMBL38163 | — | — | 1 | - |
| CHEMBL288288 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289351 | FOSBRETABULIN DISODIUM | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL37688 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL34720 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL289910 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL36775 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL37961 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL38061 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL284289 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL38163 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL288288 | — | IC50 | > | 25000.0 | nM | - |