Assay Detail
Binding
CHEMBL717443
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Inhibitory activity against matrix metalloprotease-13 (MMP13)
34
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Stereospecific synthesis of 5-substituted 2-bisarylthiocyclopentane carboxylic acids as specific matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.52 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126461 | — | — | 1 | 8.92 |
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 8.82 |
| CHEMBL341249 | — | — | 1 | 8.74 |
| CHEMBL339588 | — | — | 1 | 8.72 |
| CHEMBL127787 | — | — | 1 | 8.55 |
| CHEMBL126712 | — | — | 1 | 8.51 |
| CHEMBL115653 | CIPEMASTAT | 2.0 | 1 | 8.47 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.47 |
| CHEMBL126380 | — | — | 3 | 8.30 |
| CHEMBL127138 | — | — | 1 | 8.29 |
| CHEMBL340771 | — | — | 1 | 7.96 |
| CHEMBL514138 | CGS-27023A | — | 1 | 7.92 |
| CHEMBL337946 | — | — | 1 | 7.89 |
| CHEMBL125104 | — | — | 1 | 7.82 |
| CHEMBL338877 | — | — | 1 | 7.57 |
| CHEMBL127168 | — | — | 1 | 7.51 |
| CHEMBL127867 | — | — | 1 | 7.50 |
| CHEMBL126977 | — | — | 1 | 7.18 |
| CHEMBL126711 | — | — | 1 | 7.10 |
| CHEMBL340455 | — | — | 1 | 6.89 |
| CHEMBL127035 | — | — | 1 | 6.88 |
| CHEMBL126923 | — | — | 1 | 6.79 |
| CHEMBL339610 | — | — | 1 | 6.71 |
| CHEMBL123503 | — | — | 1 | 6.61 |
| CHEMBL125901 | — | — | 1 | 6.56 |
| CHEMBL337986 | — | — | 1 | 6.53 |
| CHEMBL339137 | — | — | 1 | 6.41 |
| CHEMBL125138 | — | — | 1 | 6.38 |
| CHEMBL340345 | — | — | 1 | 6.17 |
| CHEMBL127559 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126461 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL341249 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL339588 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL127787 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL126712 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL115653 | CIPEMASTAT | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL126380 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL127138 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL340771 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL337946 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL125104 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL338877 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL126380 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL127168 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL127867 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL126977 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL126711 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL340455 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL127035 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL126923 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL126380 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL339610 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL123503 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL125901 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL337986 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL339137 | — | IC50 | = | 391.0 | nM | 6.41 |
| CHEMBL125138 | — | IC50 | = | 417.0 | nM | 6.38 |
| CHEMBL340345 | — | IC50 | = | 682.0 | nM | 6.17 |
| CHEMBL127559 | — | IC50 | = | 808.0 | nM | 6.09 |
| CHEMBL339315 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL125302 | — | IC50 | > | 100.0 | nM | - |