Assay Detail
Binding
CHEMBL718063
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Inhibitory potency against Matrix metalloprotease-1 (MMP-1)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Beta-aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.90 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL433314 | — | — | 1 | 9.22 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 9.15 |
| CHEMBL72511 | — | — | 1 | 8.96 |
| CHEMBL306090 | — | — | 1 | 8.70 |
| CHEMBL76297 | — | — | 1 | 8.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL433314 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL279785 | MARIMASTAT | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL72511 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL306090 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL76297 | — | Ki | = | 3.5 | nM | 8.46 |