Assay Detail
Binding
CHEMBL718189
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Binding affinity towards human Melanocortin 3 receptor (hMC3R)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Sub-nanomolar hMC1R agonists by end-capping of the melanocortin tetrapeptide His-D-Phe-Arg-Trp-NH(2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.73 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 9.17 |
| CHEMBL431801 | — | — | 1 | 7.87 |
| CHEMBL92481 | — | — | 1 | 7.70 |
| CHEMBL432565 | — | — | 1 | 7.19 |
| CHEMBL89004 | — | — | 1 | 7.18 |
| CHEMBL419307 | — | — | 1 | 6.96 |
| CHEMBL315356 | — | — | 1 | 6.89 |
| CHEMBL312998 | — | — | 1 | 6.85 |
| CHEMBL328117 | — | — | 1 | 6.80 |
| CHEMBL406276 | — | — | 1 | 6.77 |
| CHEMBL329586 | — | — | 1 | 6.68 |
| CHEMBL327450 | — | — | 1 | 6.64 |
| CHEMBL316259 | — | — | 1 | 6.58 |
| CHEMBL313377 | — | — | 1 | 6.55 |
| CHEMBL88630 | — | — | 1 | 6.46 |
| CHEMBL315258 | — | — | 1 | 6.42 |
| CHEMBL88537 | — | — | 1 | 6.36 |
| CHEMBL91957 | — | — | 1 | 6.36 |
| CHEMBL407825 | — | — | 1 | 6.27 |
| CHEMBL86573 | — | — | 1 | 6.27 |
| CHEMBL264306 | — | — | 1 | 6.24 |
| CHEMBL316038 | — | — | 1 | 6.20 |
| CHEMBL50056 | — | — | 1 | 6.11 |
| CHEMBL89270 | — | — | 1 | 6.05 |
| CHEMBL88185 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL431801 | — | Ki | = | 13.5 | nM | 7.87 |
| CHEMBL92481 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL432565 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL89004 | — | Ki | = | 66.5 | nM | 7.18 |
| CHEMBL419307 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL315356 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL312998 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL328117 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL406276 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL329586 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL327450 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL316259 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL313377 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL88630 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL315258 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL88537 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL91957 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL407825 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL86573 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL264306 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL316038 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL50056 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL89270 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL88185 | — | Ki | = | 1900.0 | nM | 5.72 |