Assay Detail
Binding
CHEMBL718222
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Binding affinity at Metabotropic glutamate receptor 2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.92 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8759 | EGLUMETAD | 2.0 | 1 | 7.89 |
| CHEMBL284193 | — | — | 1 | 6.96 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 5.92 |
| CHEMBL279956 | QUISQUALATE | — | 1 | - |
| CHEMBL33567 | — | — | 1 | - |
| CHEMBL39221 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8759 | EGLUMETAD | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL284193 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL279956 | QUISQUALATE | Ki | = | 113000.0 | nM | - |
| CHEMBL33567 | — | Ki | = | 129000.0 | nM | - |
| CHEMBL39221 | — | Ki | > | 1000000.0 | nM | - |