Assay Detail
Functional
CHEMBL718227
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Antagonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated in presence of 30 uM glutamic acid
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 2 (CHEMBL2851) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 4.61 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL341888 | — | — | 1 | 4.77 |
| CHEMBL144201 | — | — | 1 | 4.44 |
| CHEMBL121053 | — | — | 1 | - |
| CHEMBL144678 | — | — | 1 | - |
| CHEMBL333519 | — | — | 1 | - |
| CHEMBL334014 | — | — | 1 | - |
| CHEMBL144747 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL341888 | — | EC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL144201 | — | EC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL121053 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL144678 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL333519 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL334014 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL144747 | — | EC50 | > | 100000.0 | nM | - |