Assay Detail
Functional
CHEMBL718352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate receptor 3
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.18 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144151 | — | — | 1 | 7.80 |
| CHEMBL2311086 | — | — | 1 | 6.55 |
| CHEMBL2112583 | — | — | 1 | 6.33 |
| CHEMBL2112584 | — | — | 1 | 6.26 |
| CHEMBL2112581 | — | — | 1 | 6.24 |
| CHEMBL2112582 | — | — | 1 | 6.19 |
| CHEMBL2112586 | — | — | 1 | 6.12 |
| CHEMBL2112580 | — | — | 1 | 5.92 |
| CHEMBL2112574 | — | — | 1 | 5.85 |
| CHEMBL331753 | — | — | 1 | 5.75 |
| CHEMBL2112579 | — | — | 1 | 5.60 |
| CHEMBL2112585 | — | — | 1 | 5.55 |
| CHEMBL333487 | — | — | 1 | - |
| CHEMBL332141 | — | — | 1 | - |
| CHEMBL325500 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144151 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2311086 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2112583 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL2112584 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2112581 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL2112582 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2112586 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL2112580 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2112574 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL331753 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2112579 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2112585 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL333487 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL332141 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL325500 | — | IC50 | > | 10000.0 | nM | - |