Assay Detail
Binding
CHEMBL718684
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against the catalytic domain of the human matrix metalloprotease-1
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.36 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109353 | — | — | 1 | 6.68 |
| CHEMBL321213 | — | — | 1 | 6.58 |
| CHEMBL109806 | — | — | 1 | 6.52 |
| CHEMBL111179 | — | — | 1 | 6.44 |
| CHEMBL422250 | — | — | 1 | 6.41 |
| CHEMBL111450 | — | — | 1 | 6.40 |
| CHEMBL110970 | — | — | 1 | 6.38 |
| CHEMBL109770 | — | — | 1 | 6.37 |
| CHEMBL109579 | — | — | 1 | 6.36 |
| CHEMBL111678 | — | — | 1 | 6.35 |
| CHEMBL109214 | — | — | 1 | 6.34 |
| CHEMBL422251 | — | — | 1 | 6.26 |
| CHEMBL419750 | — | — | 1 | 6.24 |
| CHEMBL322795 | — | — | 1 | 6.20 |
| CHEMBL111257 | — | — | 1 | 6.19 |
| CHEMBL109861 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109353 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL321213 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL109806 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL111179 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL422250 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL111450 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL110970 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL109770 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL109579 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL111678 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL109214 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL422251 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL419750 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL322795 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL111257 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL109861 | — | Ki | = | 1040.0 | nM | 5.98 |