Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL718685

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human Matrix metalloprotease-1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Interstitial collagenase (CHEMBL332)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Sultam hydroxamates as novel matrix metalloproteinase inhibitors.
Cherney RJ, Mo R, Meyer DT, Hardman KD, Liu RQ, Covington MB, Qian M, Wasserman ZR, Christ DD, Trzaskos JM, Newton RC, Decicco CP.
J Med Chem (2004) 47 : 2981 -2983
PubMed 15163180 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 6.00 6.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL101789 1 6.50
CHEMBL103418 1 6.03
CHEMBL322433 1 5.96
CHEMBL103563 1 5.50
CHEMBL319075 1 -
CHEMBL321055 1 -
CHEMBL99733 1 -
CHEMBL100570 1 -
CHEMBL329043 1 -
CHEMBL100754 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL101789 Ki = 318.0 nM 6.50
CHEMBL103418 Ki = 938.0 nM 6.03
CHEMBL322433 Ki = 1085.0 nM 5.96
CHEMBL103563 Ki = 3166.0 nM 5.50
CHEMBL319075 Ki > 4949.0 nM -
CHEMBL321055 Ki > 4949.0 nM -
CHEMBL99733 Ki > 4949.0 nM -
CHEMBL100570 Ki > 4949.0 nM -
CHEMBL329043 Ki > 4949.0 nM -
CHEMBL100754 Ki > 4949.0 nM -