Assay Detail
Binding
CHEMBL718686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against matrix metalloprotease-1 (MMP-1)(recombinant human collagenase-1).
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New type of metalloproteinase inhibitor: design and synthesis of new phosphonamide-based hydroxamic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.97 | 9.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL172885 | — | — | 1 | 9.01 |
| CHEMBL355797 | — | — | 1 | 8.74 |
| CHEMBL172249 | — | — | 1 | 8.70 |
| CHEMBL173027 | — | — | 1 | 8.50 |
| CHEMBL170315 | — | — | 1 | 8.44 |
| CHEMBL173316 | — | — | 1 | 8.39 |
| CHEMBL174315 | — | — | 1 | 8.35 |
| CHEMBL366478 | — | — | 1 | 8.34 |
| CHEMBL172886 | — | — | 1 | 8.31 |
| CHEMBL368205 | — | — | 1 | 8.27 |
| CHEMBL425316 | — | — | 1 | 8.19 |
| CHEMBL173846 | — | — | 1 | 8.18 |
| CHEMBL368857 | — | — | 1 | 8.17 |
| CHEMBL173754 | — | — | 1 | 8.13 |
| CHEMBL177072 | — | — | 1 | 8.11 |
| CHEMBL539171 | — | — | 1 | 8.02 |
| CHEMBL171962 | — | — | 1 | 7.97 |
| CHEMBL171292 | — | — | 1 | 7.97 |
| CHEMBL170429 | — | — | 1 | 7.96 |
| CHEMBL172548 | — | — | 1 | 7.94 |
| CHEMBL171986 | — | — | 1 | 7.76 |
| CHEMBL173744 | — | — | 1 | 7.75 |
| CHEMBL367710 | — | — | 1 | 7.73 |
| CHEMBL173235 | — | — | 1 | 7.70 |
| CHEMBL175164 | — | — | 1 | 7.68 |
| CHEMBL173326 | — | — | 1 | 7.62 |
| CHEMBL172415 | — | — | 1 | 7.57 |
| CHEMBL173686 | — | — | 1 | 7.40 |
| CHEMBL436049 | — | — | 1 | 7.23 |
| CHEMBL172722 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL172885 | — | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL355797 | — | Ki | = | 1.81 | nM | 8.74 |
| CHEMBL172249 | — | Ki | = | 2.02 | nM | 8.70 |
| CHEMBL173027 | — | Ki | = | 3.14 | nM | 8.50 |
| CHEMBL170315 | — | Ki | = | 3.64 | nM | 8.44 |
| CHEMBL173316 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL174315 | — | Ki | = | 4.43 | nM | 8.35 |
| CHEMBL366478 | — | Ki | = | 4.58 | nM | 8.34 |
| CHEMBL172886 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL368205 | — | Ki | = | 5.39 | nM | 8.27 |
| CHEMBL425316 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL173846 | — | Ki | = | 6.67 | nM | 8.18 |
| CHEMBL368857 | — | Ki | = | 6.75 | nM | 8.17 |
| CHEMBL173754 | — | Ki | = | 7.33 | nM | 8.13 |
| CHEMBL177072 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL539171 | — | Ki | = | 9.65 | nM | 8.02 |
| CHEMBL171292 | — | Ki | = | 10.7 | nM | 7.97 |
| CHEMBL171962 | — | Ki | = | 10.7 | nM | 7.97 |
| CHEMBL170429 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL172548 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL171986 | — | Ki | = | 17.4 | nM | 7.76 |
| CHEMBL173744 | — | Ki | = | 17.8 | nM | 7.75 |
| CHEMBL367710 | — | Ki | = | 18.7 | nM | 7.73 |
| CHEMBL173235 | — | Ki | = | 20.1 | nM | 7.70 |
| CHEMBL175164 | — | Ki | = | 20.8 | nM | 7.68 |
| CHEMBL173326 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL172415 | — | Ki | = | 27.1 | nM | 7.57 |
| CHEMBL173686 | — | Ki | = | 39.8 | nM | 7.40 |
| CHEMBL436049 | — | Ki | = | 58.8 | nM | 7.23 |
| CHEMBL172722 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL418655 | — | Ki | = | 759.0 | nM | 6.12 |
| CHEMBL174014 | — | Ki | > | 850.0 | nM | - |
| CHEMBL433981 | — | Ki | > | 850.0 | nM | - |
| CHEMBL172181 | — | Ki | > | 850.0 | nM | - |
| CHEMBL353536 | — | Ki | > | 850.0 | nM | - |