Assay Detail
Binding
CHEMBL718691
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against matrix metalloprotease-1
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 64 | 6.38 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293503 | — | — | 1 | 8.52 |
| CHEMBL123775 | — | — | 1 | 8.40 |
| CHEMBL122711 | — | — | 1 | 8.22 |
| CHEMBL340461 | — | — | 1 | 8.22 |
| CHEMBL306726 | — | — | 1 | 8.15 |
| CHEMBL332755 | — | — | 1 | 8.15 |
| CHEMBL123463 | — | — | 1 | 8.15 |
| CHEMBL262676 | — | — | 1 | 8.15 |
| CHEMBL432223 | — | — | 1 | 8.00 |
| CHEMBL331311 | — | — | 1 | 7.80 |
| CHEMBL330857 | — | — | 1 | 7.68 |
| CHEMBL304281 | — | — | 1 | 7.62 |
| CHEMBL122719 | — | — | 1 | 7.60 |
| CHEMBL332120 | — | — | 1 | 7.60 |
| CHEMBL123041 | — | — | 1 | 7.58 |
| CHEMBL293774 | — | — | 1 | 7.55 |
| CHEMBL441084 | — | — | 1 | 7.52 |
| CHEMBL122831 | — | — | 1 | 7.43 |
| CHEMBL450327 | — | — | 1 | 7.41 |
| CHEMBL311336 | — | — | 1 | 7.37 |
| CHEMBL331342 | — | — | 1 | 7.36 |
| CHEMBL440714 | — | — | 1 | 7.28 |
| CHEMBL122651 | — | — | 1 | 7.27 |
| CHEMBL316169 | — | — | 1 | 7.24 |
| CHEMBL82868 | — | — | 1 | 7.22 |
| CHEMBL122836 | — | — | 1 | 7.22 |
| CHEMBL55110 | — | — | 1 | 7.21 |
| CHEMBL333532 | — | — | 1 | 7.10 |
| CHEMBL332406 | — | — | 1 | 6.86 |
| CHEMBL123167 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293503 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL123775 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL340461 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL122711 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL306726 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL332755 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL123463 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL262676 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL432223 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL331311 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL330857 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL304281 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL332120 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL122719 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL123041 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL293774 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL441084 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL122831 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL450327 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL311336 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL331342 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL440714 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL122651 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL316169 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL122836 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL82868 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL55110 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL333532 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL332406 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL123167 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL331669 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL120049 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL122925 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL332362 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL123233 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL122950 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL331114 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL122868 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL123105 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL121592 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL123064 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL121729 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL121501 | — | Ki | = | 59000.0 | nM | 4.23 |
| CHEMBL121559 | — | Ki | = | 65000.0 | nM | 4.19 |
| CHEMBL120934 | — | Ki | = | 66000.0 | nM | 4.18 |
| CHEMBL122109 | — | Ki | = | 70000.0 | nM | 4.16 |
| CHEMBL301469 | — | Ki | = | 71000.0 | nM | 4.15 |
| CHEMBL123404 | — | Ki | = | 71000.0 | nM | 4.15 |
| CHEMBL332439 | — | Ki | = | 74000.0 | nM | 4.13 |
| CHEMBL332145 | — | Ki | = | 74000.0 | nM | 4.13 |