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Assay Detail

CHEMBL718692

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against the Matrix Metalloprotease 1 (MMP-1)
ChEMBL ↗
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Interstitial collagenase (CHEMBL332) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Protease inhibitors: synthesis of potent bacterial collagenase and matrix metalloproteinase inhibitors incorporating N-4-nitrobenzylsulfonylglycine hydroxamate moieties.
Scozzafava A, Supuran CT.
J Med Chem (2000) 43 : 1858 -1865
PubMed 10794702 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 68 7.48 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL293503 — — 1 8.52
CHEMBL54054 — — 1 8.30
CHEMBL301786 — — 1 8.05
CHEMBL299023 — — 1 7.92
CHEMBL54697 — — 1 7.85
CHEMBL298822 — — 1 7.85
CHEMBL298606 — — 1 7.82
CHEMBL293305 — — 1 7.77
CHEMBL292431 — — 1 7.75
CHEMBL53044 — — 1 7.75
CHEMBL51862 — — 1 7.72
CHEMBL53094 — — 1 7.68
CHEMBL52994 — — 1 7.68
CHEMBL53457 — — 1 7.66
CHEMBL53091 — — 1 7.62
CHEMBL53051 — — 1 7.62
CHEMBL54965 — — 1 7.62
CHEMBL55907 — — 1 7.62
CHEMBL55154 — — 1 7.60
CHEMBL56951 — — 1 7.60
CHEMBL301977 — — 1 7.60
CHEMBL280017 — — 1 7.58
CHEMBL55107 — — 1 7.58
CHEMBL293774 — — 1 7.55
CHEMBL54981 — — 1 7.54
CHEMBL53949 — — 1 7.52
CHEMBL56065 — — 1 7.52
CHEMBL299600 — — 1 7.51
CHEMBL54915 — — 1 7.51
CHEMBL54617 — — 1 7.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL293503 — Ki = 3.0 nM 8.52
CHEMBL54054 — Ki = 5.0 nM 8.30
CHEMBL301786 — Ki = 9.0 nM 8.05
CHEMBL299023 — Ki = 12.0 nM 7.92
CHEMBL54697 — Ki = 14.0 nM 7.85
CHEMBL298822 — Ki = 14.0 nM 7.85
CHEMBL298606 — Ki = 15.0 nM 7.82
CHEMBL293305 — Ki = 17.0 nM 7.77
CHEMBL292431 — Ki = 18.0 nM 7.75
CHEMBL53044 — Ki = 18.0 nM 7.75
CHEMBL51862 — Ki = 19.0 nM 7.72
CHEMBL53094 — Ki = 21.0 nM 7.68
CHEMBL52994 — Ki = 21.0 nM 7.68
CHEMBL53457 — Ki = 22.0 nM 7.66
CHEMBL55907 — Ki = 24.0 nM 7.62
CHEMBL53051 — Ki = 24.0 nM 7.62
CHEMBL54965 — Ki = 24.0 nM 7.62
CHEMBL53091 — Ki = 24.0 nM 7.62
CHEMBL55154 — Ki = 25.0 nM 7.60
CHEMBL56951 — Ki = 25.0 nM 7.60
CHEMBL301977 — Ki = 25.0 nM 7.60
CHEMBL280017 — Ki = 26.0 nM 7.58
CHEMBL55107 — Ki = 26.0 nM 7.58
CHEMBL293774 — Ki = 28.0 nM 7.55
CHEMBL54981 — Ki = 29.0 nM 7.54
CHEMBL53949 — Ki = 30.0 nM 7.52
CHEMBL56065 — Ki = 30.0 nM 7.52
CHEMBL299600 — Ki = 31.0 nM 7.51
CHEMBL54915 — Ki = 31.0 nM 7.51
CHEMBL54617 — Ki = 32.0 nM 7.50
CHEMBL417200 — Ki = 33.0 nM 7.48
CHEMBL54436 — Ki = 34.0 nM 7.47
CHEMBL299091 — Ki = 36.0 nM 7.44
CHEMBL54535 — Ki = 37.0 nM 7.43
CHEMBL54621 — Ki = 39.0 nM 7.41
CHEMBL56025 — Ki = 41.0 nM 7.39
CHEMBL300807 — Ki = 43.0 nM 7.37
CHEMBL300362 — Ki = 46.0 nM 7.34
CHEMBL55984 — Ki = 49.0 nM 7.31
CHEMBL55522 — Ki = 50.0 nM 7.30
CHEMBL54483 — Ki = 50.0 nM 7.30
CHEMBL53847 — Ki = 53.0 nM 7.28
CHEMBL52531 — Ki = 54.0 nM 7.27
CHEMBL293357 — Ki = 54.0 nM 7.27
CHEMBL293528 — Ki = 55.0 nM 7.26
CHEMBL301085 — Ki = 58.0 nM 7.24
CHEMBL55744 — Ki = 59.0 nM 7.23
CHEMBL56498 — Ki = 60.0 nM 7.22
CHEMBL417749 — Ki = 62.0 nM 7.21
CHEMBL297488 — Ki = 62.0 nM 7.21