Assay Detail
Binding
CHEMBL718694
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Inhibition of human matrix metalloprotease-1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Receptor flexibility in the in silico screening of reagents in the S1' pocket of human collagenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.69 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330040 | — | — | 1 | 8.52 |
| CHEMBL293503 | — | — | 1 | 8.30 |
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 8.09 |
| CHEMBL93687 | — | — | 1 | 7.16 |
| CHEMBL410418 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330040 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL293503 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL75094 | PRINOMASTAT | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL93687 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL410418 | — | Ki | = | 423.0 | nM | 6.37 |