Assay Detail
Binding
CHEMBL718847
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Recombinant human matrix metalloprotease-1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.60 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.96 |
| CHEMBL330727 | — | — | 1 | 7.58 |
| CHEMBL92767 | — | — | 1 | 7.08 |
| CHEMBL317307 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279785 | MARIMASTAT | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL330727 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL92767 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL317307 | — | Ki | = | 162.0 | nM | 6.79 |