Assay Detail
Binding
CHEMBL718849
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Inhibitory constant against matrix metalloprotease-1
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A new concept for multidimensional selection of ligand conformations (MultiSelect) and multidimensional scoring (MultiScore) of protein-ligand binding affinities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 5.50 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77754 | — | — | 1 | 8.11 |
| CHEMBL308533 | — | — | 1 | 6.87 |
| CHEMBL76158 | — | — | 1 | 6.71 |
| CHEMBL75403 | — | — | 1 | 6.69 |
| CHEMBL308511 | — | — | 1 | 6.53 |
| CHEMBL264859 | — | — | 1 | 6.52 |
| CHEMBL77057 | — | — | 1 | 6.50 |
| CHEMBL74308 | — | — | 1 | 6.50 |
| CHEMBL306608 | — | — | 1 | 6.50 |
| CHEMBL74040 | — | — | 1 | 6.48 |
| CHEMBL422058 | — | — | 1 | 6.42 |
| CHEMBL306947 | — | — | 1 | 6.42 |
| CHEMBL306033 | — | — | 1 | 6.34 |
| CHEMBL77808 | — | — | 1 | 6.21 |
| CHEMBL77663 | — | — | 1 | 6.19 |
| CHEMBL312076 | — | — | 1 | 6.04 |
| CHEMBL306256 | — | — | 1 | 6.03 |
| CHEMBL77659 | — | — | 1 | 5.98 |
| CHEMBL310037 | — | — | 1 | 5.82 |
| CHEMBL76869 | — | — | 1 | 5.77 |
| CHEMBL311397 | — | — | 1 | 5.61 |
| CHEMBL73803 | — | — | 1 | 5.60 |
| CHEMBL76519 | — | — | 1 | 5.30 |
| CHEMBL415074 | — | — | 1 | 5.29 |
| CHEMBL91055 | — | — | 1 | 4.70 |
| CHEMBL77461 | — | — | 1 | 4.68 |
| CHEMBL307365 | — | — | 1 | 4.66 |
| CHEMBL307211 | — | — | 1 | 4.66 |
| CHEMBL74977 | — | — | 1 | 4.60 |
| CHEMBL77956 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77754 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL308533 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL76158 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL75403 | — | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL308511 | — | Ki | = | 296.0 | nM | 6.53 |
| CHEMBL264859 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL77057 | — | Ki | = | 313.0 | nM | 6.50 |
| CHEMBL74308 | — | Ki | = | 313.0 | nM | 6.50 |
| CHEMBL306608 | — | Ki | = | 319.0 | nM | 6.50 |
| CHEMBL74040 | — | Ki | = | 329.0 | nM | 6.48 |
| CHEMBL306947 | — | Ki | = | 385.0 | nM | 6.42 |
| CHEMBL422058 | — | Ki | = | 382.0 | nM | 6.42 |
| CHEMBL306033 | — | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL77808 | — | Ki | = | 618.0 | nM | 6.21 |
| CHEMBL77663 | — | Ki | = | 642.0 | nM | 6.19 |
| CHEMBL312076 | — | Ki | = | 921.0 | nM | 6.04 |
| CHEMBL306256 | — | Ki | = | 942.0 | nM | 6.03 |
| CHEMBL77659 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL310037 | — | Ki | = | 1530.0 | nM | 5.82 |
| CHEMBL76869 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL311397 | — | Ki | = | 2440.0 | nM | 5.61 |
| CHEMBL73803 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL76519 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL415074 | — | Ki | = | 5120.0 | nM | 5.29 |
| CHEMBL91055 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL77461 | — | Ki | = | 21100.0 | nM | 4.68 |
| CHEMBL307365 | — | Ki | = | 22100.0 | nM | 4.66 |
| CHEMBL307211 | — | Ki | = | 22100.0 | nM | 4.66 |
| CHEMBL74977 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL77956 | — | Ki | = | 28400.0 | nM | 4.55 |
| CHEMBL432346 | — | Ki | = | 40200.0 | nM | 4.40 |
| CHEMBL75148 | — | Ki | = | 41400.0 | nM | 4.38 |
| CHEMBL78335 | — | Ki | = | 47800.0 | nM | 4.32 |
| CHEMBL420376 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL78047 | — | Ki | = | 57800.0 | nM | 4.24 |
| CHEMBL309067 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL306779 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL306177 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL307027 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL307207 | — | Ki | = | 100000.0 | nM | 4.00 |