Assay Detail
Binding
CHEMBL718850
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of human MMP-1.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.54 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45631 | — | — | 1 | 8.92 |
| CHEMBL90337 | — | — | 1 | 8.85 |
| CHEMBL328090 | — | — | 1 | 8.74 |
| CHEMBL48258 | — | — | 1 | 8.55 |
| CHEMBL88520 | — | — | 1 | 8.52 |
| CHEMBL433381 | — | — | 1 | 8.28 |
| CHEMBL91636 | — | — | 1 | 7.89 |
| CHEMBL88718 | — | — | 1 | - |
| CHEMBL313199 | — | — | 1 | - |
| CHEMBL92385 | — | — | 1 | - |
| CHEMBL88220 | — | — | 1 | - |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | - |
| CHEMBL88427 | — | — | 1 | - |
| CHEMBL329124 | — | — | 1 | - |
| CHEMBL23725 | — | — | 1 | - |
| CHEMBL24761 | — | — | 1 | - |
| CHEMBL417537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45631 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL90337 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL328090 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL48258 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL88520 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL433381 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL91636 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL88718 | — | Ki | < | 1.0 | nM | - |
| CHEMBL313199 | — | Ki | < | 1.0 | nM | - |
| CHEMBL92385 | — | Ki | < | 1.0 | nM | - |
| CHEMBL88220 | — | Ki | < | 1.0 | nM | - |
| CHEMBL279785 | MARIMASTAT | Ki | < | 1.0 | nM | - |
| CHEMBL88427 | — | Ki | < | 1.0 | nM | - |
| CHEMBL329124 | — | Ki | < | 1.0 | nM | - |
| CHEMBL23725 | — | Ki | < | 1.0 | nM | - |
| CHEMBL24761 | — | Ki | < | 1.0 | nM | - |
| CHEMBL417537 | — | Ki | < | 1.0 | nM | - |