Assay Detail
Binding
CHEMBL718977
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Inhibition of Matrix metalloprotease-9
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Macrocyclic amino carboxylates as selective MMP-8 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.67 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48256 | — | — | 1 | 6.54 |
| CHEMBL48786 | — | — | 1 | 6.39 |
| CHEMBL298167 | — | — | 1 | 5.24 |
| CHEMBL50228 | — | — | 1 | 5.18 |
| CHEMBL46183 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48256 | — | Ki | = | 288.0 | nM | 6.54 |
| CHEMBL48786 | — | Ki | = | 404.0 | nM | 6.39 |
| CHEMBL298167 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL50228 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL46183 | — | Ki | = | 9800.0 | nM | 5.01 |