Assay Detail
Functional
CHEMBL719088
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Metabotropic glutamate receptor 1 agonist activity as basal [3H]- IP formation in rat
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Metabotropic glutamate receptor 1 (CHEMBL4477) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 4.57 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280563 | — | — | 1 | 4.64 |
| CHEMBL143210 | — | — | 1 | 4.50 |
| CHEMBL277475 | — | — | 1 | - |
| CHEMBL140197 | — | — | 2 | - |
| CHEMBL33567 | — | — | 1 | - |
| CHEMBL143267 | — | — | 1 | - |
| CHEMBL343994 | — | — | 1 | - |
| CHEMBL334160 | — | — | 1 | - |
| CHEMBL284193 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280563 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL143210 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL277475 | — | EC50 | > | 500000.0 | nM | - |
| CHEMBL140197 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL33567 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL143267 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL343994 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL334160 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL140197 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL284193 | — | EC50 | > | 100000.0 | nM | - |