Assay Detail
Binding
CHEMBL728381
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Inhibition of bovine brain mitochondrial Monoamine oxidase B (MAO-B) compared to toloxatone
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.13 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18101 | (R/R)BEFLOXATONE | — | 1 | 6.66 |
| CHEMBL17562 | — | — | 1 | 5.70 |
| CHEMBL1794849 | — | — | 1 | 5.70 |
| CHEMBL17981 | — | — | 1 | 5.36 |
| CHEMBL17653 | — | — | 1 | 5.05 |
| CHEMBL18116 | TOLOXATONE | 4.0 | 1 | 4.82 |
| CHEMBL18390 | — | — | 1 | 4.64 |
| CHEMBL279544 | — | — | 1 | 4.62 |
| CHEMBL17643 | — | — | 1 | 4.47 |
| CHEMBL18334 | — | — | 1 | 4.30 |
| CHEMBL274947 | — | — | 1 | - |
| CHEMBL18019 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18101 | (R/R)BEFLOXATONE | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL17562 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL1794849 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL17981 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL17653 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL18116 | TOLOXATONE | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL18390 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL279544 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL17643 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL18334 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL274947 | — | Ki | = | 140000.0 | nM | - |
| CHEMBL18019 | — | Ki | = | 200000.0 | nM | - |