Assay Detail
Binding
CHEMBL728700
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against Monoamine oxidase B of rat brain homogenates; value ranges from 0.0035-0.053
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.36 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 8.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | IC50 | = | 4.4 | nM | 8.36 |