Assay Detail
Functional
CHEMBL728745
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Cytotoxicity against human Molt 4/C8 cells.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Molt4/C8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A conformational and structure-activity relationship study of cytotoxic 3,5-bis(arylidene)-4-piperidones and related N-acryloyl analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.66 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158037 | — | — | 1 | 6.82 |
| CHEMBL350032 | — | — | 1 | 6.39 |
| CHEMBL152675 | — | — | 1 | 6.36 |
| CHEMBL152674 | — | — | 1 | 5.98 |
| CHEMBL156016 | — | — | 1 | 5.85 |
| CHEMBL154716 | — | — | 1 | 5.78 |
| CHEMBL155539 | — | — | 1 | 5.64 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.49 |
| CHEMBL358894 | — | — | 1 | 5.30 |
| CHEMBL348877 | — | — | 1 | 5.08 |
| CHEMBL347880 | — | — | 1 | 4.87 |
| CHEMBL154880 | — | — | 1 | 4.40 |
| CHEMBL151678 | — | — | 1 | - |
| CHEMBL152243 | — | — | 1 | - |
| CHEMBL151677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158037 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL350032 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL152675 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL152674 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL156016 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL154716 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL155539 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL852 | MELPHALAN | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL358894 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL348877 | — | IC50 | = | 8280.0 | nM | 5.08 |
| CHEMBL347880 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL154880 | — | IC50 | = | 40200.0 | nM | 4.40 |
| CHEMBL151678 | — | IC50 | = | 288000.0 | nM | - |
| CHEMBL152243 | — | IC50 | = | 369000.0 | nM | - |
| CHEMBL151677 | — | IC50 | = | 226000.0 | nM | - |