Assay Detail
Functional
CHEMBL729378
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Antiproliferative activity was determined against human T-lymphocyte cells -Molt4/C8
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Deoxyribonucleoside 2'- or 3'-mixed disulfides: prodrugs to target ribonucleotide reductase and/or to inhibit HIV reverse transcription.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.60 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450901 | — | — | 1 | 4.60 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
| CHEMBL444845 | — | — | 1 | - |
| CHEMBL62684 | — | — | 1 | - |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | - |
| CHEMBL87718 | — | — | 1 | - |
| CHEMBL85821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450901 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL129 | ZIDOVUDINE | IC50 | > | 375000.0 | nM | - |
| CHEMBL444845 | — | IC50 | = | 255000.0 | nM | - |
| CHEMBL62684 | — | IC50 | = | 325000.0 | nM | - |
| CHEMBL483 | TENOFOVIR ANHYDROUS | IC50 | > | 350000.0 | nM | - |
| CHEMBL87718 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL85821 | — | IC50 | = | 650000.0 | nM | - |