Assay Detail
Binding
CHEMBL729453
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit Monoamine oxidase B enzyme
66
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Inhibition of monoamine oxidase-B by 5H-indeno[1,2-c]pyridazines: biological activities, quantitative structure-activity relationships (QSARs) and 3D-QSARs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 66 | 5.17 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127983 | — | — | 1 | 7.05 |
| CHEMBL127774 | — | — | 1 | 6.55 |
| CHEMBL124935 | — | — | 1 | 6.30 |
| CHEMBL127622 | — | — | 1 | 6.18 |
| CHEMBL127182 | — | — | 1 | 6.15 |
| CHEMBL339626 | — | — | 1 | 6.05 |
| CHEMBL340701 | — | — | 1 | 6.04 |
| CHEMBL125921 | — | — | 1 | 6.04 |
| CHEMBL127517 | — | — | 1 | 6.04 |
| CHEMBL339535 | — | — | 1 | 6.00 |
| CHEMBL339739 | — | — | 1 | 6.00 |
| CHEMBL127717 | — | — | 1 | 6.00 |
| CHEMBL127077 | — | — | 1 | 6.00 |
| CHEMBL338094 | — | — | 1 | 5.88 |
| CHEMBL125520 | — | — | 1 | 5.88 |
| CHEMBL125843 | — | — | 1 | 5.82 |
| CHEMBL125094 | — | — | 1 | 5.80 |
| CHEMBL339565 | — | — | 1 | 5.75 |
| CHEMBL339429 | — | — | 1 | 5.66 |
| CHEMBL127982 | — | — | 1 | 5.66 |
| CHEMBL125044 | — | — | 1 | 5.49 |
| CHEMBL339027 | — | — | 1 | 5.43 |
| CHEMBL127751 | — | — | 1 | 5.38 |
| CHEMBL339470 | — | — | 1 | 5.29 |
| CHEMBL419614 | — | — | 1 | 5.28 |
| CHEMBL126027 | — | — | 1 | 5.11 |
| CHEMBL128029 | — | — | 1 | 5.02 |
| CHEMBL124461 | — | — | 1 | 5.00 |
| CHEMBL127757 | — | — | 1 | 5.00 |
| CHEMBL126419 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127983 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL127774 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL124935 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL127622 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL127182 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL339626 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL340701 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL125921 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL127517 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL339535 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL339739 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL127717 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL127077 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL125520 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL338094 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL125843 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL125094 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL339565 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL339429 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL127982 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL125044 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL339027 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL127751 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL339470 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL419614 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL126027 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL128029 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL124461 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL127757 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL126419 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL126891 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL127347 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL127518 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL126547 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL127966 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL126504 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL421088 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL126505 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL129769 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL341240 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL124867 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL339561 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL338035 | — | IC50 | = | 30600.0 | nM | 4.51 |
| CHEMBL420523 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL339794 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL127567 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL340130 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL340028 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL341071 | — | IC50 | = | 74400.0 | nM | 4.13 |
| CHEMBL123895 | — | IC50 | = | 80100.0 | nM | 4.10 |