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Assay Detail

CHEMBL729464

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory concentration against Monoamine oxidase B of rat brain homogenates
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Brain
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Amine oxidase [flavin-containing] B (CHEMBL2993)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.
Sterling J, Herzig Y, Goren T, Finkelstein N, Lerner D, Goldenberg W, Miskolczi I, Molnar S, Rantal F, Tamas T, Toth G, Zagyva A, Zekany A, Finberg J, Lavian G, Gross A, Friedman R, Razin M, Huang W, Krais B, Chorev M, Youdim MB, Weinstock M.
J Med Chem (2002) 45 : 5260 -5279
PubMed 12431053 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 6.69 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL436947 1 8.00
CHEMBL2096744 1 7.30
CHEMBL1235738 AZILECT 1 4.77
CHEMBL544635 1 -
CHEMBL554452 1 -
CHEMBL555919 1 -
CHEMBL545333 1 -
CHEMBL1788299 1 -
CHEMBL151236 1 -
CHEMBL542506 1 -
CHEMBL542749 1 -
CHEMBL544396 1 -
CHEMBL1788300 1 -
CHEMBL545566 1 -
CHEMBL544636 1 -
CHEMBL555641 1 -
CHEMBL542266 1 -
CHEMBL545797 1 -
CHEMBL151861 1 -
CHEMBL147033 1 -
CHEMBL556028 1 -
CHEMBL1788296 1 -
CHEMBL151194 1 -
CHEMBL359288 1 -
CHEMBL147524 1 -
CHEMBL151368 1 -
CHEMBL2093014 1 -
CHEMBL542265 1 -
CHEMBL544398 1 -
CHEMBL347527 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL436947 IC50 = 10.0 nM 8.00
CHEMBL2096744 IC50 = 50.0 nM 7.30
CHEMBL1235738 AZILECT IC50 = 17000.0 nM 4.77
CHEMBL544636 IC50 > 1000000.0 nM -
CHEMBL544637 IC50 > 1000000.0 nM -
CHEMBL545566 IC50 > 1000000.0 nM -
CHEMBL1788300 IC50 > 1000000.0 nM -
CHEMBL544396 IC50 > 1000000.0 nM -
CHEMBL542749 IC50 > 1000000.0 nM -
CHEMBL542506 IC50 > 1000000.0 nM -
CHEMBL151236 IC50 > 1000000.0 nM -
CHEMBL1788299 IC50 > 1000000.0 nM -
CHEMBL545333 IC50 > 1000000.0 nM -
CHEMBL555919 IC50 > 1000000.0 nM -
CHEMBL554452 IC50 > 1000000.0 nM -
CHEMBL544635 IC50 > 1000000.0 nM -
CHEMBL545104 IC50 > 1000000.0 nM -
CHEMBL151369 IC50 > 1000000.0 nM -
CHEMBL555641 IC50 > 1000000.0 nM -
CHEMBL542266 IC50 > 1000000.0 nM -
CHEMBL545797 IC50 > 1000000.0 nM -
CHEMBL151861 IC50 > 1000000.0 nM -
CHEMBL147033 IC50 = 1000000.0 nM -
CHEMBL556028 IC50 > 1000000.0 nM -
CHEMBL1788296 IC50 > 1000000.0 nM -
CHEMBL151194 IC50 > 1000000.0 nM -
CHEMBL359288 IC50 > 1000000.0 nM -
CHEMBL147524 IC50 > 1000000.0 nM -
CHEMBL151368 IC50 > 1000000.0 nM -
CHEMBL2093014 IC50 > 1000000.0 nM -
CHEMBL542265 IC50 > 1000000.0 nM -
CHEMBL544398 IC50 > 1000000.0 nM -
CHEMBL347527 IC50 > 1000000.0 nM -