Assay Detail
Functional
CHEMBL729970
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Inhibition of VEGF-stimulated migration of human microvascular endothelial cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Endothelial cell |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Lysyl 4-aminobenzoic acid derivatives as potent small molecule mimetics of plasminogen kringle 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.96 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176441 | — | — | 1 | 11.00 |
| CHEMBL433611 | — | — | 1 | 10.70 |
| CHEMBL173266 | — | — | 1 | 10.22 |
| CHEMBL368362 | — | — | 1 | 8.96 |
| CHEMBL422381 | — | — | 1 | 8.92 |
| CHEMBL263988 | — | — | 1 | - |
| CHEMBL174903 | — | — | 1 | - |
| CHEMBL368395 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176441 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL433611 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL173266 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL368362 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL422381 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL263988 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL174903 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL368395 | — | IC50 | > | 100.0 | nM | - |