Assay Detail
Binding
CHEMBL731909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.79 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118651 | — | — | 1 | 7.55 |
| CHEMBL325706 | — | — | 1 | 7.36 |
| CHEMBL334215 | — | — | 1 | 7.20 |
| CHEMBL118768 | — | — | 1 | 7.19 |
| CHEMBL325854 | — | — | 1 | 7.11 |
| CHEMBL118466 | — | — | 1 | 7.03 |
| CHEMBL333243 | — | — | 1 | 6.95 |
| CHEMBL118187 | — | — | 1 | 6.85 |
| CHEMBL117109 | — | — | 1 | 6.82 |
| CHEMBL334184 | — | — | 1 | 6.77 |
| CHEMBL119675 | — | — | 1 | 6.45 |
| CHEMBL434409 | — | — | 1 | 6.17 |
| CHEMBL331842 | — | — | 1 | 6.05 |
| CHEMBL118917 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118651 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL325706 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL334215 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL118768 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL325854 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL118466 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL333243 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL118187 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL117109 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL334184 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL119675 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL434409 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL331842 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL118917 | — | IC50 | = | 2600.0 | nM | 5.58 |