Assay Detail
Binding
CHEMBL732094
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In vitro inhibitory activity determined against human mitogen-activated protein kinase p38 alpha
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.25 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL152208 | — | — | 1 | 8.40 |
| CHEMBL356455 | — | — | 1 | 8.30 |
| CHEMBL155567 | — | — | 1 | 8.15 |
| CHEMBL152767 | — | — | 1 | 8.00 |
| CHEMBL153265 | — | — | 1 | 7.92 |
| CHEMBL152820 | — | — | 1 | 7.89 |
| CHEMBL155508 | — | — | 1 | 7.68 |
| CHEMBL119385 | NEFLAMAPIMOD | 2.0 | 1 | 7.54 |
| CHEMBL357732 | — | — | 1 | 7.54 |
| CHEMBL279416 | VK-19911 | — | 1 | 7.42 |
| CHEMBL347496 | — | — | 1 | 7.41 |
| CHEMBL153012 | — | — | 1 | 7.38 |
| CHEMBL152440 | — | — | 1 | 7.27 |
| CHEMBL422510 | — | — | 1 | 7.20 |
| CHEMBL347770 | — | — | 1 | 7.00 |
| CHEMBL155448 | — | — | 1 | 6.86 |
| CHEMBL356157 | — | — | 1 | 6.84 |
| CHEMBL152596 | — | — | 1 | 6.84 |
| CHEMBL152349 | — | — | 1 | 6.71 |
| CHEMBL347576 | — | — | 1 | 6.36 |
| CHEMBL152209 | — | — | 1 | 6.24 |
| CHEMBL356809 | — | — | 1 | 6.09 |
| CHEMBL152403 | — | — | 1 | 5.81 |
| CHEMBL153795 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL152208 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL356455 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL155567 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL152767 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL153265 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL152820 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL155508 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL119385 | NEFLAMAPIMOD | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL357732 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL279416 | VK-19911 | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL347496 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL153012 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL152440 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL422510 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL347770 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL155448 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL356157 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL152596 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL152349 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL347576 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL152209 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL356809 | — | IC50 | = | 811.0 | nM | 6.09 |
| CHEMBL152403 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL153795 | — | IC50 | > | 100000.0 | nM | - |