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Assay Detail

CHEMBL732613

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Functional
Inhibition of p38 MAP kinase related interleukin (IL1-beta (cytokine) release from human whole blood
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Tissue Blood
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

MAP kinase p38 (CHEMBL2094115)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

From imidazoles to pyrimidines: new inhibitors of cytokine release.
Laufer SA, Wagner GK.
J Med Chem (2002) 45 : 2733 -2740
PubMed 12061876 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.05 5.56

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL111456 1 5.56
CHEMBL358814 1 5.40
CHEMBL143370 1 5.39
CHEMBL313417 1 4.57
CHEMBL92723 1 4.34
CHEMBL92070 1 -
CHEMBL94086 1 -
CHEMBL92724 1 -
CHEMBL93574 1 -
CHEMBL93914 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL111456 IC50 = 2780.0 nM 5.56
CHEMBL358814 IC50 = 4000.0 nM 5.40
CHEMBL143370 IC50 = 4100.0 nM 5.39
CHEMBL313417 IC50 = 27000.0 nM 4.57
CHEMBL92723 IC50 = 45500.0 nM 4.34
CHEMBL92070 IC50 > 100000.0 nM -
CHEMBL94086 IC50 > 100000.0 nM -
CHEMBL92724 IC50 > 100000.0 nM -
CHEMBL93574 IC50 > 100000.0 nM -
CHEMBL93914 IC50 > 100000.0 nM -