Assay Detail
Functional
CHEMBL732614
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Inhibition of p38 MAP kinase related interleukin (IL1-beta (cytokine) release from human whole blood
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
From imidazoles to pyrimidines: new inhibitors of cytokine release.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.35 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313417 | — | — | 1 | 6.28 |
| CHEMBL111456 | — | — | 1 | 6.06 |
| CHEMBL358814 | — | — | 1 | 6.05 |
| CHEMBL143370 | — | — | 1 | 6.00 |
| CHEMBL441811 | — | — | 1 | 5.64 |
| CHEMBL93079 | — | — | 1 | 5.27 |
| CHEMBL92723 | — | — | 1 | 5.25 |
| CHEMBL93914 | — | — | 1 | 5.13 |
| CHEMBL92070 | — | — | 1 | 5.11 |
| CHEMBL94086 | — | — | 1 | 4.75 |
| CHEMBL93574 | — | — | 1 | 4.59 |
| CHEMBL92724 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313417 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL111456 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL358814 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL143370 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL441811 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL93079 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL92723 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL93914 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL92070 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL94086 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL93574 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL92724 | — | IC50 | = | 75500.0 | nM | 4.12 |