Assay Detail
Binding
CHEMBL732617
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Binding affinity for human recombinant Mitogen-activated protein kinase p38 in a fluorescent binding assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 44 | 7.28 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420047 | — | — | 1 | 9.00 |
| CHEMBL84777 | — | — | 1 | 8.70 |
| CHEMBL315100 | — | — | 1 | 8.52 |
| CHEMBL86318 | — | — | 1 | 8.52 |
| CHEMBL100847 | — | — | 1 | 8.52 |
| CHEMBL314228 | — | — | 1 | 8.40 |
| CHEMBL312873 | — | — | 1 | 8.30 |
| CHEMBL314805 | — | — | 1 | 8.15 |
| CHEMBL315059 | — | — | 1 | 8.10 |
| CHEMBL85860 | — | — | 1 | 8.10 |
| CHEMBL10 | SB-203580 | — | 1 | 8.00 |
| CHEMBL315023 | — | — | 1 | 7.92 |
| CHEMBL314023 | — | — | 1 | 7.89 |
| CHEMBL420231 | — | — | 1 | 7.85 |
| CHEMBL85461 | — | — | 1 | 7.85 |
| CHEMBL87224 | — | — | 1 | 7.72 |
| CHEMBL314278 | — | — | 1 | 7.68 |
| CHEMBL87289 | — | — | 1 | 7.66 |
| CHEMBL87580 | — | — | 1 | 7.60 |
| CHEMBL312895 | — | — | 1 | 7.51 |
| CHEMBL84928 | — | — | 1 | 7.33 |
| CHEMBL101035 | — | — | 1 | 7.06 |
| CHEMBL86195 | — | — | 1 | 7.00 |
| CHEMBL85942 | — | — | 1 | 6.89 |
| CHEMBL85609 | — | — | 1 | 6.70 |
| CHEMBL407173 | — | — | 1 | 6.58 |
| CHEMBL83254 | — | — | 1 | 6.55 |
| CHEMBL85985 | — | — | 1 | 6.50 |
| CHEMBL88096 | — | — | 1 | 6.48 |
| CHEMBL87277 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420047 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL84777 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL86318 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL100847 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL315100 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL314228 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL312873 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL314805 | — | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL315059 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL85860 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL10 | SB-203580 | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL315023 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL314023 | — | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL420231 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL85461 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL87224 | — | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL314278 | — | Kd | = | 21.0 | nM | 7.68 |
| CHEMBL87289 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL87580 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL312895 | — | Kd | = | 31.0 | nM | 7.51 |
| CHEMBL84928 | — | Kd | = | 47.0 | nM | 7.33 |
| CHEMBL101035 | — | Kd | = | 88.0 | nM | 7.06 |
| CHEMBL86195 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL85942 | — | Kd | = | 130.0 | nM | 6.89 |
| CHEMBL85609 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL407173 | — | Kd | = | 260.0 | nM | 6.58 |
| CHEMBL83254 | — | Kd | = | 280.0 | nM | 6.55 |
| CHEMBL85985 | — | Kd | = | 318.0 | nM | 6.50 |
| CHEMBL88096 | — | Kd | = | 330.0 | nM | 6.48 |
| CHEMBL87277 | — | Kd | = | 350.0 | nM | 6.46 |
| CHEMBL313202 | — | Kd | = | 400.0 | nM | 6.40 |
| CHEMBL423862 | — | Kd | = | 420.0 | nM | 6.38 |
| CHEMBL87830 | — | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL103676 | — | Kd | = | 530.0 | nM | 6.28 |
| CHEMBL87257 | — | Kd | = | 760.0 | nM | 6.12 |
| CHEMBL87018 | — | Kd | = | 1200.0 | nM | 5.92 |
| CHEMBL89154 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL317876 | — | Kd | = | 1500.0 | nM | 5.82 |
| CHEMBL319681 | — | Kd | = | 7500.0 | nM | 5.12 |
| CHEMBL103275 | — | Kd | > | 900.0 | nM | - |
| CHEMBL86962 | — | Kd | > | 7000.0 | nM | - |
| CHEMBL313515 | — | Kd | > | 7000.0 | nM | - |
| CHEMBL87610 | — | Kd | > | 400.0 | nM | - |
| CHEMBL316570 | — | Kd | > | 1000.0 | nM | - |