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Assay Detail

CHEMBL732618

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against human Mitogen-activated protein kinase p38
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

MAP kinase p38 (CHEMBL2094115)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate.
Regan J, Breitfelder S, Cirillo P, Gilmore T, Graham AG, Hickey E, Klaus B, Madwed J, Moriak M, Moss N, Pargellis C, Pav S, Proto A, Swinamer A, Tong L, Torcellini C.
J Med Chem (2002) 45 : 2994 -3008
PubMed 12086485 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 6.51 6.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL101035 1 6.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL101035 Kd = 310.0 nM 6.51