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Assay Detail

CHEMBL732620

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Binding
Evaluated for inhibition of human mitogen-activated protein kinase p38
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

MAP kinase p38 (CHEMBL2094115)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

General model for estimation of the inhibition of protein kinases using Monte Carlo simulations.
Tominaga Y, Jorgensen WL.
J Med Chem (2004) 47 : 2534 -2549
PubMed 15115396 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 36 7.36 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL420047 1 9.00
CHEMBL84777 1 8.70
CHEMBL315100 1 8.52
CHEMBL86318 1 8.52
CHEMBL314228 1 8.40
CHEMBL312873 1 8.30
CHEMBL314805 1 8.15
CHEMBL315059 1 8.10
CHEMBL85860 1 8.10
CHEMBL315023 1 7.92
CHEMBL314023 1 7.89
CHEMBL420231 1 7.85
CHEMBL85461 1 7.85
CHEMBL87224 1 7.72
CHEMBL314278 1 7.68
CHEMBL87289 1 7.66
CHEMBL87580 1 7.60
CHEMBL312895 1 7.51
CHEMBL84928 1 7.33
CHEMBL86195 1 7.00
CHEMBL85942 1 6.89
CHEMBL85609 1 6.70
CHEMBL407173 1 6.58
CHEMBL83254 1 6.55
CHEMBL85985 1 6.50
CHEMBL88096 1 6.48
CHEMBL87277 1 6.46
CHEMBL313202 1 6.40
CHEMBL423862 1 6.38
CHEMBL87830 1 6.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL420047 Kd = 1.0 nM 9.00
CHEMBL84777 Kd = 2.0 nM 8.70
CHEMBL86318 Kd = 3.0 nM 8.52
CHEMBL315100 Kd = 3.0 nM 8.52
CHEMBL314228 Kd = 4.0 nM 8.40
CHEMBL312873 Kd = 5.0 nM 8.30
CHEMBL314805 Kd = 7.0 nM 8.15
CHEMBL315059 Kd = 8.0 nM 8.10
CHEMBL85860 Kd = 8.0 nM 8.10
CHEMBL315023 Kd = 12.0 nM 7.92
CHEMBL314023 Kd = 13.0 nM 7.89
CHEMBL420231 Kd = 14.0 nM 7.85
CHEMBL85461 Kd = 14.0 nM 7.85
CHEMBL87224 Kd = 19.0 nM 7.72
CHEMBL314278 Kd = 21.0 nM 7.68
CHEMBL87289 Kd = 22.0 nM 7.66
CHEMBL87580 Kd = 25.0 nM 7.60
CHEMBL312895 Kd = 31.0 nM 7.51
CHEMBL84928 Kd = 47.0 nM 7.33
CHEMBL86195 Kd = 100.0 nM 7.00
CHEMBL85942 Kd = 130.0 nM 6.89
CHEMBL85609 Kd = 200.0 nM 6.70
CHEMBL407173 Kd = 260.0 nM 6.58
CHEMBL83254 Kd = 280.0 nM 6.55
CHEMBL85985 Kd = 318.0 nM 6.50
CHEMBL88096 Kd = 330.0 nM 6.48
CHEMBL87277 Kd = 350.0 nM 6.46
CHEMBL313202 Kd = 400.0 nM 6.40
CHEMBL423862 Kd = 420.0 nM 6.38
CHEMBL87830 Kd = 500.0 nM 6.30
CHEMBL87257 Kd = 760.0 nM 6.12
CHEMBL87018 Kd = 1200.0 nM 5.92
CHEMBL89154 Kd = 1400.0 nM 5.85
CHEMBL313515 Kd > 7000.0 nM -
CHEMBL86962 Kd > 7000.0 nM -
CHEMBL87610 Kd > 400.0 nM -