Assay Detail
Binding
CHEMBL732623
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against Mitogen-activated protein kinase p38
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.34 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129678 | — | — | 1 | 8.17 |
| CHEMBL126676 | — | — | 1 | 7.60 |
| CHEMBL129677 | — | — | 1 | 7.11 |
| CHEMBL341280 | — | — | 1 | 6.96 |
| CHEMBL129153 | — | — | 1 | 6.60 |
| CHEMBL338196 | — | — | 1 | 6.55 |
| CHEMBL130025 | — | — | 1 | 6.40 |
| CHEMBL126180 | — | — | 1 | 6.29 |
| CHEMBL118928 | — | — | 1 | 6.25 |
| CHEMBL261454 | — | — | 1 | 6.13 |
| CHEMBL340203 | — | — | 1 | 5.89 |
| CHEMBL341534 | — | — | 1 | 5.64 |
| CHEMBL129760 | — | — | 1 | 5.27 |
| CHEMBL337978 | — | — | 1 | 5.17 |
| CHEMBL338713 | — | — | 1 | 5.11 |
| CHEMBL129280 | — | — | 1 | - |
| CHEMBL125846 | — | — | 1 | - |
| CHEMBL125738 | — | — | 1 | - |
| CHEMBL129553 | — | — | 1 | - |
| CHEMBL126789 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129678 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL126676 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL129677 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL341280 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL129153 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL338196 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL130025 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL126180 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL118928 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL261454 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL340203 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL341534 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL129760 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL337978 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL338713 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL129280 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL125846 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL125738 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL129553 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL126789 | — | IC50 | > | 20000.0 | nM | - |