Assay Detail
Binding
CHEMBL732625
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Inhibition of Mitogen-activated protein kinase p38 (P38 MAPK)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Imidazole inhibitors of cytokine release: probing substituents in the 2 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.62 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10 | SB-203580 | — | 1 | 6.54 |
| CHEMBL113419 | — | — | 1 | 6.20 |
| CHEMBL87858 | — | — | 1 | 6.16 |
| CHEMBL359380 | — | — | 1 | 6.12 |
| CHEMBL358042 | — | — | 1 | 5.85 |
| CHEMBL356485 | — | — | 1 | 5.82 |
| CHEMBL143370 | — | — | 1 | 5.68 |
| CHEMBL357648 | — | — | 1 | 5.64 |
| CHEMBL142841 | — | — | 1 | 5.47 |
| CHEMBL142891 | — | — | 1 | 5.42 |
| CHEMBL356983 | — | — | 1 | 5.42 |
| CHEMBL111456 | — | — | 1 | 5.40 |
| CHEMBL143007 | — | — | 1 | 5.24 |
| CHEMBL143480 | — | — | 1 | 4.92 |
| CHEMBL142751 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10 | SB-203580 | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL113419 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL87858 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL359380 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL358042 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL356485 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL143370 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL357648 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL142841 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL142891 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL356983 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL111456 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL143007 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL143480 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL142751 | — | IC50 | = | 35000.0 | nM | 4.46 |