Assay Detail
Functional
CHEMBL732631
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Inhibition of p38 kinase related TNF-alpha release
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
p38 Inhibitors: piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.72 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356754 | — | — | 1 | 8.31 |
| CHEMBL356125 | — | — | 1 | 8.26 |
| CHEMBL328242 | — | — | 1 | 8.25 |
| CHEMBL343682 | — | — | 1 | 8.00 |
| CHEMBL358108 | — | — | 1 | 7.89 |
| CHEMBL357598 | — | — | 1 | 7.75 |
| CHEMBL142187 | — | — | 1 | 7.70 |
| CHEMBL142697 | — | — | 1 | 7.62 |
| CHEMBL142289 | — | — | 1 | 7.62 |
| CHEMBL142050 | — | — | 1 | 7.51 |
| CHEMBL327987 | — | — | 1 | 7.44 |
| CHEMBL142463 | — | — | 1 | 7.29 |
| CHEMBL356994 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356754 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL356125 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL328242 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL343682 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL358108 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL357598 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL142187 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL142697 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL142289 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL142050 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL327987 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL142463 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL356994 | — | IC50 | = | 200.0 | nM | 6.70 |